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DTSTART:20260329T030000
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DTSTAMP:20260415T110122Z
UID:1770026400@ist.ac.at
DTSTART:20260202T110000
DTEND:20260202T123000
DESCRIPTION:Speaker: Kirti Jain\nhosted by Alicia Michael\nAbstract: The m
 ultiple antibiotic resistance (mar) operon is one of the largest regulo
 ns in Escherichia coli. The mar locus encodes an autorepressor\, MarR\;
  an autoactivator\, MarA\; and MarB\, a protein of unknown function and vi
 a MarA regulates a wide variety of downstream targets involved in cellu
 lar processes such as efflux\, pH response\, porin regulation\, etc. Al
 though this system has been extensively studied for its role in antibiot
 ic resistance\, the role of basal expression has largely been overlooked a
 nd dismissed as promoter leakiness.Our work explores the basal expression 
 mode of the mar operon and shows that it is dynamic\, consisting of rare
  stochastic gene expression pulses. These pulses maximize phenotypic va
 riability in wild-type populations and\, unexpectedly\, transiently accele
 rate cellular elongation rates. At the molecular level\, this behavior i
 s linked to an unusual yet evolutionarily conserved GTG start codon in ma
 rR\, suggesting that natural selection has preserved this dynamic expressi
 on pattern across many related gut bacteria. Together\, these findings de
 monstrate that even so-called “leaky” uninduced gene expression can be
  a selected feature with meaningful ecological and physiological consequen
 ces\, reshaping our understanding of gene regulation in microbes.Kirti Jai
 n is a Postdoc Award Recipient of 2025.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:diana.gruber@ista.ac.at
SUMMARY:Kirti Jain: Basal Gene Expression Dynamics in Bacteria 
URL:https://talks-calendar.ista.ac.at/events/6168
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