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DTSTART:20260329T030000
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BEGIN:VEVENT
DTSTAMP:20260425T193328Z
UID:1764592200@ist.ac.at
DTSTART:20251201T133000
DTEND:20251201T143000
DESCRIPTION:Speaker: Raquel Casado Polanco\nhosted by Johann Danzl\nAbstrac
 t: Radial glial progenitors (RGPs) generate all excitatory neurons and cer
 tain glial lineages that populate the mature neocortex. The NOTCH signalin
 g pathway plays a pivotal role during brain development\, mediating the ba
 lance between stem cell self-renewal and differentiation. The NOTCH1 recep
 tor is broadly expressed at the membrane surface of RGPs. Previous studies
  reported that loss of Notch1 results in precocious progenitor differentia
 tion and neurogenesis\, affects gliogenesis\, and results in brain morphol
 ogical abnormalities. However\, the precise role of Notch1 at single-RGP l
 evel remains elusive. Here\, we used Mosaic Analysis with Double Markers (
 MADM) to assess the cell-autonomous function and tissue-wide effects of No
 tch1 at single-cell level. We showed that sparse deletion of Notch1 reduce
 d the number of neurons and nearly eradicated the astrocyte population in 
 the mouse neocortex. In contrast\, tissue-wide Notch1 ablation did not aff
 ect neurogenic or astrogenic output\, but rather showed some features rese
 mbling human focal cortical dysplasia phenotypes. Altogether\, taking adva
 ntage of the single-cell resolution of MADM\, these data revealed distinct
  cell-autonomous and tissue-wide effects of Notch1 in neocortical developm
 ent.
LOCATION:Central Bldg / O1 / Lecture Hall (I02.O1.014)\, ISTA
ORGANIZER:
SUMMARY:Raquel Casado Polanco: Thesis Defense: Role of NOTCH Signaling in R
 adial Glial Progenitor Lineage Progression
URL:https://talks-calendar.ista.ac.at/events/6151
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