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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260428T144419Z
UID:590b24a89062d934731020@ist.ac.at
DTSTART:20170519T110000
DTEND:20170519T120000
DESCRIPTION:Speaker: Ofer Yizhar\nhosted by Harald Janovjak\nAbstract: The 
 basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) are pla
 y key roles in coordinating the acquisition and extinction of learned fear
  associations. Strong reciprocal monosynaptic excitatory connections link 
 these two regions\, forming a recurrent synaptic circuit that is thought t
 o carry important information regarding salient sensory cues during learni
 ng. Whereas mPFC input to BLA was shown to play a major role in fear extin
 ction\, the reciprocal pathway has received less attention. To address the
  role of this pathway in fear learning\, we examined the utility of inhibi
 tory optogenetic tools for silencing synaptic terminals. Surprisingly\, we
  found that while proton-pumping microbial rhodopsins are effective in sil
 encing evoked release\, they induce a paradoxical increase in spontaneous 
 neurotransmission under minutes-long light stimulation. Furthermore\, expe
 riments utilizing chloride-conducting channelrhodopsins showed that the re
 versal potential for chloride in the axon is depolarized relative to the r
 esting membrane potential\, leading to excitation upon light activation of
  these optogenetic tools in the axonal compartment. We therefore devised a
 n optogenetic stimulation protocol that triggers long-term synaptic depres
 sion in BLA axonal terminals onto mPFC cells. In behaving mice\, synaptic 
 depression of BLA inputs to the mPFC impaired the consolidation of cued\, 
 but not contextual associations. Induction of synaptic depression in this 
 pathway during extinction training led to suppression of neuronal response
 s to fear-associated cues in mPFC units\, and facilitated extinction learn
 ing. Our findings demonstrate the pivotal role of the monosynaptic BLA inp
 ut to the mPFC in the consolidation and extinction of cued fear memories.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:amally@ist.ac.at
SUMMARY:Ofer Yizhar: Optogenetic analysis of amygdala-prefrontal connection
 s in learning
URL:https://talks-calendar.ista.ac.at/events/611
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