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DTSTART:20260329T030000
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DTSTAMP:20260425T105055Z
UID:68e7b64fe34b8491235158@ist.ac.at
DTSTART:20251120T130000
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DESCRIPTION:Speaker: Beatrice Ramm\nhosted by Martin Loose\nAbstract: A hal
 lmark of living systems is self-organized pattern formation: the partition
 ing of molecules and cells into distinct spatial domains with different fu
 nctions. But self-organization phenomenaexhibit complex behavior that cann
 ot be predicted from their components\, complicating theirinvestigation. T
 o overcome this challenge\, our research uses bottom-up and mammalian synt
 hetic biology approaches to quantitatively describe the molecular mechanis
 ms and emergent properties of self-organizing systems. In this talk\, I wi
 ll describe with two examples how we study the pattern formation of bacter
 ial protein systems using in vitro reconstitution techniques.The first exa
 mple is the Escherichia coli MinDE system\, which positions the cell divis
 ion site and has become a model for pattern formation because it self-orga
 nizes into traveling surface waves and other patterns when reconstituted. 
 Using this technique\, we discovered that MinDE can transport unrelated ca
 rgo molecules via a nonspecific mechanism termed diffusiophoresis.The seco
 nd example consists of a phosphatidylinositol (PI) lipid kinase\, MavQ\, a
 nd a phosphatase\, SidP\, two effector proteins of the intracellular patho
 genic bacterium Legionella pneumophila\, thathave been shown to remodel ER
  membranes of the eukaryotic host cell\, while exhibiting dynamics. We cou
 ld show that MavQ and SidP also self-organize into dynamic patterns that e
 nrich their substrate lipids in vitro. I will discuss how MavQ/SidP self-o
 rganization differs from established systems such as E. coli MinDE\, sugge
 sting it may be a promising new paradigm for the study of protein pattern 
 formation.
LOCATION:Central Bldg / O1 / Mondi 2a (I01.O1.008)\, ISTA
ORGANIZER:rpacarad@ist.ac.at
SUMMARY:Beatrice Ramm: Self-organization and molecular transport by bacteri
 al protein systems
URL:https://talks-calendar.ista.ac.at/events/6095
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