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DTSTART:20260329T030000
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DTSTAMP:20260424T143306Z
UID:1762329600@ist.ac.at
DTSTART:20251105T090000
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DESCRIPTION:Speaker: Marko Kojic\nhosted by Beatriz Vicoso\nAbstract: Life 
 on Earth emerged when early biomolecules became enclosed within flexible m
 embranes\, creating confined spaces that enabled essential reactions and d
 rove evolution. This membrane flexibility remains crucial today\, especial
 ly during cell division\, where cells undergo dramatic shape changes to co
 nstrict at mid-cell and separate into two daughter cells. To achieve this\
 , prokaryotic cells employ a conserved protein machinery called the diviso
 me\, orchestrated by the Z-ring\, which coordinates membrane remodelling a
 nd cell envelope synthesis. The central question of this thesis is: How is
  the Z-ring precisely positioned to ensure accurate symmetric cell divisio
 n? Firstly\, n archaea\, I investigate how early division proteins assembl
 e in Haloferax volcanii to recruit FtsZ to the division site. I show that 
 a tripartite complex (SepF-CdpB1-CdpB2) forms in a defined hierarchy that 
 enables the recruitment of FtsZ2 filaments. These results reveal conserved
  features of divisome assembly with evolutionary implications for early ce
 llular life. Secondly\, in bacteria\, I examine how the Z-ring is oriented
  orthogonally relative to the long axis. My findings demonstrate that the 
 distribution of charged amino acids in the intrinsically disordered C-term
 inal linker of FtsZ determines the Z-ring diameter and allows the scaling 
 with diverse cell diameters. This part of the dissertation uncovers fundam
 ental biophysical and molecular mechanisms that control spatial divisome p
 ositioning\, which is crucial for symmetric division of unicellular organi
 sms.
LOCATION:Central Bldg / O1 / Lecture Hall (I02.O1.014)\, ISTA
ORGANIZER:
SUMMARY:Marko Kojic: Thesis Defense: TOWARDS UNDERSTANDING THE SPATIAL REGU
 LATION OF THE Z-RING IN ARCHAEA AND BACTERIA
URL:https://talks-calendar.ista.ac.at/events/6091
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