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BEGIN:VEVENT
DTSTAMP:20260428T112234Z
UID:590b07ead382c369246098@ist.ac.at
DTSTART:20170515T110000
DTEND:20170515T120000
DESCRIPTION:Speaker: Carolina Barillas-Mury\nhosted by Sylvia Cremer\nAbstr
 act: Plasmodium falciparum malaria is transmitted by anopheline mosquitoes
 . Mosquitoes can mount antiplasmodial responses that effectively limit inf
 ection of murine malaria parasites during the early stages of infections\,
  when ookinetes invade the mosquito midgut. However\, some Plasmodium falc
 iparum strains can escape these defenses and survive. We identified Pfs47\
 , as the surface protein that allows the parasite to evade mosquito immuni
 ty by disrupting JNK signaling in mosquito midgut cells. P. falciparum mal
 aria originated in Africa and became global as humans migrated to other co
 ntinents. During this journey\, parasites encountered new anopheline mosqu
 ito species that were sometimes evolutionarily distant from African vector
 s. We propose that that the mosquito immune system is a major evolutionary
  force that continuously selects the parasites circulating in a given regi
 on\, because only those parasites expressing a Pfs47 haplotype compatible 
 with a given vector species are able to evade antiplasmodial immunity and 
 survive. A new model\, the lock and key theory of P. falciparum globalizat
 ion\, will be presented and its implications will be discussed.\n
LOCATION:I22 Lakeside View (I22.01)\, ISTA
ORGANIZER:astawick@ist.ac.at
SUMMARY:Carolina Barillas-Mury: Plasmodium Evasion of Mosquito Immunity and
  Malaria Globalization
URL:https://talks-calendar.ista.ac.at/events/609
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