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BEGIN:VEVENT
DTSTAMP:20260424T040556Z
UID:1759757400@ist.ac.at
DTSTART:20251006T153000
DTEND:20251006T163000
DESCRIPTION:Speaker: Suyash Naik\nhosted by Michael Sixt\nAbstract: For tis
 sues to spread\, they must be deformable while maintaining their structura
 l integrity. How these opposing requirements are balanced within spreading
  tissues is not yet well understood. Here\, we show that keratin intermedi
 ate filaments function in epithelial spreading by adapting tissue mechanic
 al resilience to the stresses arising in the tissue during the spreading p
 rocess. By analysing the expansion of the enveloping cell layer (EVL) over
  the large yolk cell in early zebrafish embryos in vivo\, we found that ke
 ratin network maturation in EVL cells is promoted by stresses building up 
 within the spreading tissue. Through genetic interference and tissue rheol
 ogy experiments\, complemented by a vertex model with mechanochemical feed
 back\, we demonstrate that stress-induced keratin network maturation in th
 e EVL increases tissue viscosity\, which is essential for preventing tissu
 e rupture. Interestingly\, we also find that keratins are required in the 
 yolk cell for mechanosensitive actomyosin network contraction and flow\, t
 he force-generating processes that orchestrate EVL pulling. Overall\, this
  work illustrates that keratins exhibit dual mechanosensitive functions in
  development. Such duality in keratin functions enables a delicate balance
  between the production of pulling forces in the yolk cell and maintenance
  of the mechanical resilience of the EVL against stresses generated by the
 se pulling forces\, thereby ensuring uniform and robust tissue spreading.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B (I23.EG.102) and
  Zoom\, ISTA
ORGANIZER:
SUMMARY:Suyash Naik: Thesis Defense: Keratins act as global coordinators of
  tissue spreading through mechanosensitive feedback
URL:https://talks-calendar.ista.ac.at/events/6036
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