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DTSTART:20250330T030000
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DTSTAMP:20260424T114128Z
UID:68b826369cd5f123465897@ist.ac.at
DTSTART:20250924T130000
DTEND:20250924T140000
DESCRIPTION:Speaker: Shosei Yoshida\nhosted by Edouard Hannezo\nAbstract: S
 permatogenesis takes place in the testis\, relying on the ordered turnover
  of differentiating cells supplied from stem cells. Classic histological a
 nalyses have revealed that this process shows hierarchical spatiotemporal 
 patterning known as the spermatogenic cycle\, wave\, and descent of segmen
 tal order\, indicative of currently underexplored mechanisms of tissue- an
 d organ-scale homeostasis. Here\, using mice\, we conducted high-resolutio
 n\, wide-field\, and ultra long-term live imaging studies in vivo and ex v
 ivo\, combined with whole-organ mapping of differentiation stages. Such tr
 ans-scale measures demonstrate how stereotypic local cell turnover is coor
 dinated into characteristic phase waves propagating along the seminiferous
  tubules\, further organized into organ-scale patterning over the tubule l
 oops. Minimal mathematical modeling shows that such higher-order dynamics 
 can emerge from the local coupling of autonomous oscillators\, which are r
 ooted in delayed feedback interplay between stem and differentiating cells
  via retinoic acid signaling. These findings highlight a self-organization
  mechanism underpinning organ-scale homeostasis and constant sperm product
 ion.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B / 63 seats (I23.
 EG.102)\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Shosei Yoshida: Self-organization of spermatogenic wave coordinates
  sustained sperm production in the mouse testis
URL:https://talks-calendar.ista.ac.at/events/5995
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