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DTSTAMP:20260426T212710Z
UID:1757419200@ist.ac.at
DTSTART:20250909T140000
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DESCRIPTION:Speaker: Dr. Yun-Wei Lien\nhosted by Florian Schur\nAbstract: P
 redation allows bacteria to access alternative substrates in low-nutrient 
 conditions. Ixotrophy has been proposed as a predatory lifestyle of multic
 ellular filamentous bacteria in aquatic environments\; however\, the molec
 ular mechanism remains unknown.Here we uncover by a multidisciplinary appr
 oach that ixotrophy requires the interplay of multiple cellular machinerie
 s and a regulatory mechanism. Attacker-prey contacts are established by gl
 iding motility and extracellular grappling hook-like structures that bind 
 prey flagella. Cryo-electron microscopy identifies the grappling hooks as 
 a heptameric assembly of a Type 9 Secretion System substrate. Cryo-electro
 n tomography and functional assays show that killing is mediated by punctu
 ring of the prey cell using a Type 6 Secretion System\, possibly triggered
  by extracellular antennae. Single-cell analyses with stable isotope-label
 ed prey demonstrate that prey components are taken up by the attacker. Dep
 ending on nutrient availability\, ixotrophy is switched off by endogenous 
 Insertion Sequence Elements and re-activated through their excision. A mar
 ine metagenomic time series provides evidence for coupled dynamics of ixot
 rophic bacteria and their prey.Our study reveals the complex mechanism of 
 a conserved microbial predatory lifestyle and indicates the need for its r
 egulation in conditions where the expression of costly pathways is dispens
 able.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B \, ISTA
ORGANIZER:jgazsi@ist.ac.at
SUMMARY:Dr. Yun-Wei Lien: MECHANISM OF BACTERIAL PREDATION VIA IXOTROPHY
URL:https://talks-calendar.ista.ac.at/events/5992
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