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DTSTAMP:20260424T143213Z
UID:1757415600@ist.ac.at
DTSTART:20250909T130000
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DESCRIPTION:Speaker: Caterina Giannini\nhosted by Andela Saric\nAbstract: A
 uxin is a central regulator of plant growth and development\, orchestratin
 g processes from embryogenesis to senescence through a complex network of 
 biosynthesis\, transport\, and signaling pathways. In Arabidopsis thalian
 a\, canonical nuclear auxin signaling is mediated by the TIR1/AFB receptor
 s\, which promote degradation of AUX/IAA repressors to enable ARF transcri
 ption factors-driven transcriptional reprogramming. Parallel to this well-
 established nuclear mechanism\, auxin also triggers rapid\, non-transcript
 ional responses. In particular\, at the cell surface\, most notably throug
 h ABP1 and TMKs. Despite decades of research\, the integration of these pa
 thways and their links to fundamental cellular processes remains not fully
  understood. In this study\, we uncover a new role for TIR1/AFB signaling
  in rapidly activating macroautophagy during developmental reprogramming. 
 Auxin induces autophagy via TIR1/AFB adenylate cyclase activity\, linking 
 auxin perception to cAMP production and transcriptional activation of auto
 phagy machinery. Autophagy-deficient mutants exhibit delayed meristem diff
 erentiation\, impaired lateral root progression\, and reduced shoot organo
 genesis\, demonstrating its necessity for timely developmental transitions
 .We also revisit the ABP1-TMK1 cell-surface auxin perception complex\, pro
 viding biochemical and mass photometry evidence for auxin-dependent comple
 x formation. We show that ABP1-TMK1 triggers an ultrafast global phosphory
 lation response targeting ~1000 proteins\, including the auxin transporter
  PIN2\, and Rho-of-plants (ROP) GTPases regulators. This pathway directly 
 regulates PIN2 phosphorylation\, for gravitropism and auxin dependent ROP 
 activation.These findings establish an integrated framework in which nucle
 ar TIR1/AFB signaling and cell-surface ABP1-TMK signaling act in parallel 
 to synchronize gene expression\, cytoplasmic remodelling\, and transporter
  regulation\, thereby ensuring robust developmental plasticity in Arabidop
 sis thaliana. 
LOCATION:Central Bldg / O1 / Mondi 2a (I01.O1.008) and Zoom\, ISTA
ORGANIZER:
SUMMARY:Caterina Giannini: Thesis Defense: Auxin signalling in Arabidopsis 
 thaliana development
URL:https://talks-calendar.ista.ac.at/events/5964
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