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DTSTART:20260329T030000
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DTSTAMP:20260424T063500Z
UID:1773657000@ist.ac.at
DTSTART:20260316T113000
DTEND:20260316T123000
DESCRIPTION:Speaker: Sergiu Pasca\nhosted by Simon Hippenmeyer\nAbstract: A
  critical challenge in understanding the programs underlying the developme
 nt\, assembly and dysfunction of the human brain is the lack of direct acc
 ess to intact\, functioning human brain tissue for direct investigation an
 d manipulation. In this talk\, I will describe efforts in my laboratory to
  build functional cellular models and to capture previously inaccessible a
 spects of human brain development and dysfunction. To achieve this\, we ha
 ve pioneered the use of instructive signals to derive\, from pluripotent 
 stem cells\, self-organizing 3D tissue structures called regionalized neu
 ral organoids that resembles domains of the developing central nervous sys
 tem. We have shown that these cultures\, such as the ones resembling the c
 erebral cortex\, thalamus or spinal cord\, recapitulate many features of n
 eural development\, can be derived with high reliability across dozens of 
 cell lines and experiments\, and can be maintained for years in vitro to c
 apture advanced stages of neural and glial maturation and function. To mod
 el complex cell-cell interactions\, we developed assembloids and demonst
 rated their use in modeling cell migration\, formation of neural circuits
  and disease processes. To advance maturation and circuit integration of 
 organoids\, we introduced a transplantation paradigm and demonstrated that
  engrafted human neurons can respond to sensory stimulation in the animal 
 and can drive reward-seeking behavior therefore enabling behavioral readou
 ts from patient-derived cells. Lastly\, I will illustrate how these metho
 ds can be combined with modern neuroscience tools to study neuropsychiatri
 c disorders and develop therapeutics.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:diana.gruber@ista.ac.at
SUMMARY:Sergiu Pasca: Putting the Pieces Together: Inception of Human Neura
 l Circuits in Assembloids
URL:https://talks-calendar.ista.ac.at/events/5960
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