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DTSTAMP:20260426T103453Z
UID:1756983600@ist.ac.at
DTSTART:20250904T130000
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DESCRIPTION:Speaker: Bryan Wu\nhosted by Caroline Muller\nAbstract: Systems
  design has classically relied on composable systems\, in which individual
  subsystems have defined inputs\, outputs\, and interactions with each oth
 er\; however\, attempts at designing complex systems in synthetic biology 
 has often run in to issues of crosstalk and interference\, given that thes
 e systems must function within the context of the host. In nature\, mobile
  genetic elements are systems that have evolved to travel between hosts\, 
 and thus appear to be a good candidate with which to evaluate composabilit
 y. Selecting temperate phages as a model system\, I used mathematical mode
 lling to identify sources of information that temperate phages should resp
 ond to. I found that essential proteins of temperate phages can interfere 
 with potential hosts\, indicating limitations to composability. I also des
 igned a lysogeny reporter construct and characterize its behaviour across 
 various laboratory and environmental strains\, finding differences in phag
 e lambda lysogen\, and potential interference from prophages that already 
 exist within the environmental strains. Although the information gathered 
 is not conclusive\, it suggests that composability is not a key property o
 f temperate phages\, implying that biological systems may not be composabl
 e\, and that other system design principles should be considered when desi
 gning synthetic systems.
LOCATION:Central Bldg / O1 / Mondi 2b (I01.O1.008) and Zoom\, ISTA
ORGANIZER:
SUMMARY:Bryan Wu: Thesis Defense: An Examination on Phages as a Naturally C
 omposable System
URL:https://talks-calendar.ista.ac.at/events/5954
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