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DTSTART:20250330T030000
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DTSTART:20251026T020000
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BEGIN:VEVENT
DTSTAMP:20260425T105040Z
UID:685121fa95023774426614@ist.ac.at
DTSTART:20250828T100000
DTEND:20250828T110000
DESCRIPTION:Speaker: Henrik Weyer\nhosted by Martin Loose\nAbstract: Intrac
 ellular processes must be precisely organized in space and time. A paradig
 matic example is the symmetric division of bacteria\, which\, in E. coli\,
  is orchestrated by the ATP-driven oscillation of Min proteins between the
  cell poles. Remarkably\, two proteins of the Min system are sufficient fo
 r this pattern-formation process. Even so\, this seemingly simple system f
 orms a kaleidoscope of different reactiondiffusion patterns in vitro\, wit
 hout clear connections to the in vivo patterns. We lack a comprehensive un
 derstanding of the patterns in vivo and in vitro. Here\, we show theoretic
 ally that changes in the membrane-binding of one of the proteins\, MinE\, 
 explain the differences between patterns in vivo and in vitro. We verify t
 his prediction in vitro by constructing pattern phase diagrams using wild-
 type proteins and by removing MinEs membrane targeting sequence. This show
 s that a conceptual reactiondiffusion system grounded in the known biochem
 istry of the Min proteins captures their diverse spatiotemporal self-organ
 ization quantitatively\, offering an instructive platform to study the phy
 siological implications of and the physical principles underlying the rich
  phenomenology of intracellular protein patterns.
LOCATION:Office Bldg West / Ground floor / Heinzel Seminar Room (I21.EG.101
 )\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Henrik Weyer: A comprehensive view on pattern formation by the Min 
 Proteins in vivo and in vitro
URL:https://talks-calendar.ista.ac.at/events/5920
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