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DTSTAMP:20260312T162901Z
UID:68416eb5a3e16945374341@ist.ac.at
DTSTART:20250714T104500
DTEND:20250714T113000
DESCRIPTION:Speaker: Michael Murrell\nhosted by Edouard Hannezo\nAbstract: 
 Living systems are driven far from thermodynamic equilibrium through the c
 ontinuous consumption of ambient energy. This energy is invested in the fo
 rmation of complex\, internal macromolecular structures and diverse spatia
 l and temporal patterns in chemical and mechanical activities\, which in t
 urn orchestrate cell phenotypes and behaviors. This self-organization is a
  result of a system's tendency to maximize entropy production while mainta
 ining order internally. However\, a system that maximally dissipates energ
 y can achieve high levels of organization and complexity\, although this c
 omes at the cost of low thermodynamic efficiency. Despite decades of resea
 rch\, little is known regarding the energetic principles and optimization 
 strategies that constrain the dissipation of energy arbitrarily far from t
 hermodynamic equilibrium. In this seminar\, we explore energetic optimizat
 ion\, in studying the assembly of the cytokinetic ring\, a complex structu
 re that is an essential component of cellular reproduction and a defining 
 aspect of living systems. Using the Xenopus Oocyte as a model system\, we 
 measure the production of entropy\, as the cell approaches ring assembly a
 nd its first cell division. We demonstrate that en route to division\, the
  production of entropy is maximized\, but insofar as the overall system is
  bounded by energetic efficiency\, and its internal chemical and mechanica
 l activities are subject to constraints of Onsager Reciprocity. Thus\, in 
 living systems\, multiple energetic parameters are optimized simultaneousl
 y to promote and sustain life.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B / 63 seats (I23.
 EG.102)\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Michael Murrell: Energetic optimization during cell division
URL:https://talks-calendar.ista.ac.at/events/5911
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