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DTSTAMP:20260424T143420Z
UID:1751886000@ist.ac.at
DTSTART:20250707T130000
DTEND:20250707T140000
DESCRIPTION:Speaker: Patricia Rodrigues\nhosted by Florian Schur\nAbstract:
  Immune responses depend on the coordinated and efficient migration of leu
 kocytes. These cells\, which are embedded and tightly confined within tiss
 ues\, must navigate and traverse diverse and complex three-dimensional env
 ironments. Leukocytes adapt their locomotory behavior to the mechanical\, 
 geometrical\, and biochemical characteristics of their surroundings. In lo
 w-density environments\, where the pore size of the interstitial matrix al
 lows free passage\, these cells position the nucleus directly behind the l
 amellipodium\, the protrusive actin structure that forms the leading front
  of the cell. In this configuration\, they use the nucleus as a gauge to i
 dentify the path of least resistance.Here\, we show that in high-density e
 nvironments\, where the pore size precludes free passage of the cell body\
 , leukocytes reposition the microtubule-organizing center (MTOC) and assoc
 iated organelles in front of the nucleus. In this configuration\, they use
  actin structures protruding orthogonally to the direction of migration to
  open a path for the cell body.  We identify two distinct actin populatio
 ns that serve this purpose at different subcellular localizations. At the 
 leading edge\, local indentation of the plasma membrane leads to recruitme
 nt of the Wiskott-Aldrich syndrome protein (WASp)\, which\, via Arp2/3\, r
 esults in the formation of individual actin foci. At the cell body\, actin
  polymerization is triggered by DOCK8\, a Cdc42 exchange factor\, and resu
 lts in the formation of a central actin pool. We demonstrate that the cen
 tral and peripheral actin pools are functionally communicating and that de
 pletion of the central actin pool leads to increased actin accumulation at
  the cell front\, resulting in excessive extension of the leading edge.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room A (I23.EG.102) and
  Zoom\, ISTA
ORGANIZER:
SUMMARY:Patricia Rodrigues: Thesis Defense: Coordination of protrusive forc
 es in immune cell migration
URL:https://talks-calendar.ista.ac.at/events/5891
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