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DTSTART:20250330T030000
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DTSTAMP:20260312T170004Z
UID:1750680000@ist.ac.at
DTSTART:20250623T140000
DTEND:20250623T150000
DESCRIPTION:Speaker: Yiqun Wang\nhosted by Carrie Bernecky\nAbstract: Auxin
  plays a central role in plant growth and development by establishing loca
 l concentration gradients through polar transport. This process is mediate
 d by the coordinated action of auxin influx (AUX1/LAX) and efflux (PIN) ca
 rriers. The proper localization and recycling of PIN proteins are crucial 
 for auxin distribution and are regulated by clathrin-mediated endocytosis.
  Notably\, cytokinin has been shown to promote the degradation of PIN1\, p
 articularly its dephosphorylated form\, in a transcription- and translatio
 n-independent manner. However\, the mechanistic link between cytokinin sig
 naling and the endocytic machinery remains insufficiently understood. Here
 \, we identify dynamin-related proteins DRP2A and DRP2B as key components 
 in cytokinin-regulated PIN trafficking in Arabidopsis thaliana root epider
 mal cells. Although DRP2A and DRP2B are often considered functionally redu
 ndant in gametophyte development\, our findings reveal their distinct role
 s in cytokinin-mediated PIN trafficking. Single mutants of drp2a or drp2b 
 exhibit altered cytokinin-induced PIN1 degradation and PIN2 membrane dynam
 ics\, indicating non-redundant contributions to these processes. Important
 ly\, cytokinin specifically modulates the plasma membrane localization\, p
 rotein stability\, and clathrin pit recruitment of DRP2A\, but not DRP2B. 
 We further explored the role of cytokinin receptor signaling in these effe
 cts and examined how cytokinin influences the phosphorylation status of DR
 P2A\, which governs its membrane recruitment and functional assembly. Our 
 results highlight a previously unrecognized regulatory mechanism whereby c
 ytokinin fine-tunes clathrin-mediated endocytosis via post-translational m
 odulation of DRP2A\, ultimately impacting auxin transporter dynamics. Thes
 e findings uncover a novel layer of hormone crosstalk and provide mechanis
 tic insights into the regulation of membrane trafficking during plant deve
 lopment.
LOCATION:Central Bldg / O1 / Mondi 3 (I01.O1.010) and Zoom\, ISTA
ORGANIZER:
SUMMARY:Yiqun Wang: Thesis Defense: The role of dynamin related protein 2A 
 in cytokinin regulated plant growth and development
URL:https://talks-calendar.ista.ac.at/events/5857
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