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DTSTART:20260329T030000
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DTSTAMP:20260415T110123Z
UID:1773052200@ist.ac.at
DTSTART:20260309T113000
DTEND:20260309T123000
DESCRIPTION:Speaker: Ole Kiehn\nhosted by Maximilian Jösch\nAbstract: Abst
 ract:Movement is the output of almost all brain functions. Among movement\
 , locomotion is one of the most fundamental and universal to animals and h
 umans. Locomotion is organised at many levels of the nervous system\, with
  brainstem circuits acting as the gate between brain areas regulating inna
 te\, emotional\, or motivational locomotion and the executing spinal motor
  circuits. To be executed\, locomotion requires dynamic initiation and ter
 mination and appropriate directionally.This lecture will focus on recent a
 dvances that have elucidated the functional organization of brainstem comm
 and circuits in mammals needed to perform these roles. The lecture will pr
 ovide a new framework for how basal ganglia circuits are acting via these 
 brainstem circuits to elicit self-paced locomotion and how brainstem motor
  circuits may be used to define brain-wide networks involved in high-level
  behaviors. I will also discuss how locomotor disturbances following e.g.
  basal ganglia disorders may be alleviated by targeted activation of brai
 nstem and basal ganglia circuits. Biography:Ole Kiehn is Professor in Int
 egrative Neuroscience at the Department of Neuroscience\, University of Co
 penhagen\, and Professor in Neurophysiology at the Department of Neuroscie
 nce\, Karolinska Institutet. Ole Kiehn earned his medical degree from the 
 University of Copenhagen in and his Doctorate of Science from the same ins
 titution. He conducted his postdoctoral work at Cornell University before 
 returning to the University of Copenhagen as a group leader at the Institu
 te of Neurophysiology. In 2001\, he was recruited to Karolinska Institutet
 \, where he became a professor in 2004. Since 2017\, he has held a positio
 n as a professor at the Department of Neuroscience at the University of Co
 penhagen.Kiehn’s published more than 120 papers in journals including Na
 ture\, Nature Neuroscience\, Cell\, PNAS\, Science and Neuron among others
 . His research focuses on understanding the molecular\, cellular\, and fun
 ctional organization of motor circuitries in mammals. His work has uncover
 ed spinal circuits in mammals that control the ability to produce and coor
 dinate locomotor movements\, as well as brainstem command pathways that re
 gulate the expression of movement in a context-dependent manner. His work 
 links these brainstem circuits to motor circuits in the basal ganglia\, an
 d higher brain area. It provides novel insights into the role of brain cir
 cuits in the manifestation of motor disorders\, like Parkinsons Disease.Ki
 ehn has served or serve on distinguished evaluation committees\, including
  the Nobel Committee in Physiology or Medicine\, the Brain Prize Committee
  and The Novo Nordisk Prize Committee. He is the currently the President o
 f the Federation of European Neuroscience Societies. His research has been
  recognized with numerous honors\, including the Torsten and Ragnar Söder
 berg's Professorship\, The Novo Nordisk Laureate Program\, The Lundbeck Fo
 undation Professorship\, Advanced ERC grants\, the Schellenberg Prize\, th
 e Kirsten and Freddy Johansen Preclinical Prize\, and the Brain Prize 2022
 . He is an elected member of Academia Europaea\, EMBO\, the Royal Swedish 
 Academy of Science\, and The Danish Academy of Sciences and Letters.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:diana.gruber@ista.ac.at
SUMMARY:Ole Kiehn: Unraveling Circuits for Movement: Insights into Gait Mot
 or Control and Implications for Treatment for Parkinsonian Gait Disorders
URL:https://talks-calendar.ista.ac.at/events/5794
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