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DTSTART:20260329T030000
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DTSTART:20261025T020000
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BEGIN:VEVENT
DTSTAMP:20260605T185609Z
UID:1780911000@ist.ac.at
DTSTART:20260608T113000
DTEND:20260608T123000
DESCRIPTION:Speaker: Roberto di Leonardo\nhosted by Jérémie Palacci\nAbst
 ract: Many unicellular organisms can sense light\, reflecting their long e
 volutionary history in aquatic environments where sunlight provides both e
 nergy and environmental information. This has given rise to a broad divers
 ity of light-sensitive proteins that enable cells to exploit photons for m
 ultiple functions. Modern synthetic biology allows us to repurpose these n
 atural photoreceptors as biological analogues of optoelectronic components
  such as switches\, photoresistors\, and solar cells. In this talk\, I wil
 l focus on three light-activated proteins from evolutionarily diverse unic
 ellular organisms and show how they can serve as an optical interface to p
 rogram motility and gene expression. Using a light-driven proton pump\, we
  can establish feedback loops in which computer programs dynamically modul
 ate cell motility. This enables bacteria to act as light-reconfigurable pa
 int\, transport microscopic passive objects by shaping the mechanical pres
 sure of surrounding swimming cells\, and program biohybrid microrobots for
  the collection and delivery of microscopic cargo. By rewiring a cyanobact
 erial light-activated kinase into a synthetic genetic clock in E. coli\, l
 ight can serve as a zeitgeber\, driving coherent population-wide oscillati
 ons in gene expression. Finally\, we exploited the natural photophobic res
 ponse triggered by a light-activated cyclase in Euglena gracilis to design
  static “light containers” that can spatially sort cells\, leveraging 
 the non-equilibrium nature of this biological version of the billiards pro
 blem.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:diana.zubcevic@ista.ac.at
SUMMARY:Roberto di Leonardo: Programming Cell Behavior with Light
URL:https://talks-calendar.ista.ac.at/events/5793
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