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DTSTART:20260329T030000
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DTSTART:20251026T020000
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DTSTAMP:20260425T051628Z
UID:67ff75e75f9fd448271717@ist.ac.at
DTSTART:20251031T150000
DTEND:20251031T160000
DESCRIPTION:Speaker: Matthias Haering\nhosted by Edouard Hannezo\nAbstract:
  Embryonic development achieves remarkable consistency despite environment
 al fluctuations\, variable initial conditions\, or perturbations. It has b
 een shown that beyond genetic programming\, feedback mechanisms provide re
 al-time control\, coordinating cell behavior and collective dynamics. By a
 nalyzing live-imaging data from Drosophila gastrulation\, we discovered th
 at cells use mechanical signals to synchronize their activity. However\, o
 ur results also show significant variability in cell dynamics despite gene
 tic uniformity. It remains unclear whether this heterogeneity signifies ro
 bust self-organization or represents noise that must be regulated during k
 ey morphogenetic checkpoints. Quantifying heterogeneity in time series dat
 a is generally challenging due to intrinsic noise that obscures extrinsic 
 variability. I will present a reverse-time stochastic framework that (i) i
 nfers effective dynamical equations from noisy trajectories and (ii) direc
 tly decomposes observed variability into intrinsic noise and extrinsic (pa
 rameter) heterogeneity among cells. Using this method on junction constric
 tion during T1 transitions in the germband\, we find that wild-type embryo
 s show very heterogeneous constriction events\, whereas a mutant with impa
 ired T1 transitions is largely homogeneous. Revealing cell-cell variabilit
 y in time series data paves the way towards a systematic understanding of 
 heterogeneity in developmental processes.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:kiyer@ist.ac.at
SUMMARY:Matthias Haering: Robustness in epithelial morphogenesis: from mech
 anical signalling to cell heterogeneity
URL:https://talks-calendar.ista.ac.at/events/5730
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