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DTSTAMP:20260424T143512Z
UID:1746702000@ist.ac.at
DTSTART:20250508T130000
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DESCRIPTION:Speaker: Nikola Canigova\nhosted by Beatriz Vicoso\nAbstract: C
 ell migration is a crucial process in animal development and maintenance. 
 It is incredibly heterogeneous\, allowing cells to switch between migratio
 n modes depending on the cellular microenvironment. In this talk I will pr
 esent our work investigating how dendritic cells adapt their migration str
 ategy when encountering geometrically and mechanically distinct environmen
 ts. When dendritic cells are embedded in a homogeneous fibrous network\, t
 hey migrate in a fast and directional amoeboid manner. In this migration s
 trategy\, extracellular proteolysis and integrin-mediated adhesions and di
 spensable. Instead\, the cells use topography of the environment to propel
  their cell body forward. To migrate efficiently in the maze of different 
 pore sizes\, they position the nucleus ahead of the microtubule organizing
  center (MTOC) and use it to gauge the pores to identify the path of least
  resistance. Our aim was to identify whether dendritic cells adapt their m
 igration strategy when encountering asymmetrical transitions into much den
 ser environments with limited choice of large pores. Are they able to cros
 s tight pores without the use of adhesions and extracellular proteolysis a
 nd can they maintain the nucleus positioned in the cell front also during 
 such invasive transitions?
LOCATION:Central Bldg / O1 / Mondi 2a (I01.O1.008) and Zoom\, ISTA
ORGANIZER:
SUMMARY:Nikola Canigova: Adaptive strategies of dendritic cell migration in
  response to environmental cues
URL:https://talks-calendar.ista.ac.at/events/5716
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