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DTSTART:20260329T030000
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DTSTAMP:20260415T110118Z
UID:1774261800@ist.ac.at
DTSTART:20260323T113000
DTEND:20260323T123000
DESCRIPTION:Speaker: Thomas Lecuit\nhosted by Edouard Hannezo\nAbstract: Ho
 w complex and reproducible cell shapes emerge from the interplay between d
 eterministic programs and stochastic dynamics remains unclear. Using high-
 resolution in vivo imaging\, quantitative analysis\, cytoskeletal pertur
 bations and modelling\, we examine the morphogenesis of dendritic arborisa
 tions in two classes of Drosophila mechanosensory neurons with contrasti
 ng architectures. Despite sharing similar local rules for the stochastic b
 ranching dynamics\, the two classes follow divergent growth dynamics that 
 cannot be captured by standard diffusive growth models. Instead\, class-I 
 dendritic branch dynamics are subdiffusive\, and a minimal model that dist
 inguishes short and long-term branch behaviors recapitulates most features
  of growth dynamics and final morphologies. Cytoskeletal perturbations rev
 eal that actin drives short-term branch fluctuations that power arbor expa
 nsion\, whereas microtubules stabilize branches\, modulate diffusivity and
  set the final arbor size and pattern. Together\, these findings establish
  a parsimonious\, generalizable model for neuronal morphogenesis and conne
 ct local cytoskeletal regulation to global neuronal architecture\, showing
  how information encoded in the branch stochastic dynamics underlies the e
 mergence of distinct neuronal shapes.
LOCATION:ISTA | Central Building | Raiffeisen Lecture Hall\, ISTA
ORGANIZER:diana.zubcevic@ista.ac.at
SUMMARY:Thomas Lecuit: Encoding Neuronal Shape in the Stochastic Dynamics o
 f Branching Processes
URL:https://talks-calendar.ista.ac.at/events/5714
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