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DTSTART:20160327T030000
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DTSTART:20161030T020000
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DTSTAMP:20260429T142604Z
UID:55488772a3480573916629@ist.ac.at
DTSTART:20160509T124500
DTEND:20160509T134500
DESCRIPTION:Speaker: Richard Losick\nAbstract: Cell fate in biological syst
 ems is often governed deterministically by external cues or inherited pola
 rity. Sometimes\, however\, cell fate decisions are made stochastically. I
  will present two examples of noise-driven processes that govern cell fate
  choices in the bacterium Bacillus subtilis. In one cells switch stochasti
 cally between motility and chaining in a process that is controlled by sto
 chastic competition between just two proteins. As evidence that stochastic
  competition is sufficient I will show that the switch can be reconstructe
 d in the heterologous host of E. coli. The second example comes from the p
 rocess of spore formation in B. subtilis which commences with a switch fro
 m binary to asymmetric division. The cell pole at which the asymmetrically
  positioned septum is formed is chosen randomly. I will report how the sto
 chastically generated cue of the polar septum is read out to activate a ce
 ll-specific transcription factor by a protein associated with the cytokine
 tic machinery.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Richard Losick: The Institute Colloquium: Stochasticity and cell fa
 te
URL:https://talks-calendar.ista.ac.at/events/566
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