BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20250330T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20251026T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260425T075314Z
UID:1743764400@ist.ac.at
DTSTART:20250404T130000
DTEND:20250404T140000
DESCRIPTION:Speaker: Lena Schwarz\nhosted by Tim Vogels\nAbstract: In recen
 t years\, numerous studies have revealed a diverse array of genes associat
 ed with autism spectrum disorder (ASD)\, raising critical questions about 
 how mutations across various genes result in similar clinical presentation
 s. Here\, we employed single-nucleus multi-omics sequencing to analyze and
  compare 251 samples obtained from eleven distinct monogenic mouse models 
 of ASD across developmental stages\, sexes\, and two brain regions. We dis
 covered that ASD mutations commonly affect the progression of radial glial
  cells\, resulting in a delay rather than a permanent alteration in neural
  lineage specification. The most significant gene expression changes occur
 red at early postnatal stages\, primarily impacting neurons. These changes
  included a downregulation of synaptic and ion channel-related genes\, sug
 gesting potential homeostatic adaptations. Despite these similarities\, ou
 r analysis showed that each mutant is found in a distinct state with uniqu
 e and shared molecular changes. Importantly\, our study highlighted sex-sp
 ecific gene expression alterations\, with females often showing larger eff
 ect sizes than males. Altogether\, our findings provide a comprehensive vi
 ew of the cellular and molecular dynamics in different ASD models\, reveal
 ing both common and unique features across different genetic contexts.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B (I23.EG.102) and
  Zoom\, ISTA
ORGANIZER:
SUMMARY:Lena Schwarz: Thesis Defense: Mapping developmental dynamics of aut
 ism spectrum disorder mouse models at single-cell resolution
URL:https://talks-calendar.ista.ac.at/events/5650
END:VEVENT
END:VCALENDAR