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DTSTART:20250330T030000
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DTSTAMP:20260406T000409Z
UID:67ceaa73911da316140475@ist.ac.at
DTSTART:20250320T140000
DTEND:20250320T150000
DESCRIPTION:Abstract: In our laboratory\, we integrate endogenous tagging w
 ith live-cell super-resolution STED microscopy to illuminate dynamic proce
 sses occurring at the nanoscale and in the unperturbed physiological envir
 onment of the cell. We have generated a comprehensive library of proteins 
 involved in membrane homeostasis. The ability to explore endogenous cellul
 ar dynamics is revealing novel and unexplored sorting mechanisms. We have 
 provided functional characterization of a novel sorting compartment that w
 e named ARF1 compartment. ARF1 compartments orchestrate clathrin-dependent
  post-Golgi trafficking via maturing into recycling endosomes. We also stu
 dy the function of microvilli as a signaling organelle and investigate how
  signalling molecules dynamically re-organize on membrane protrusions duri
 ng chimeric antigenic receptor (CAR)–mediated activation.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:hcai@ist.ac.at
SUMMARY:Unravelling the inner secrets of cells with gene editing and live-c
 ell super-resolution microscopy | Francesca Bottanelli\, Freie Universitae
 t Berlin\, Institute for Chemistry and Biochemistry
URL:https://talks-calendar.ista.ac.at/events/5638
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