BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20250330T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20241027T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260424T221316Z
UID:67c975386c160233965598@ist.ac.at
DTSTART:20250320T130000
DTEND:20250320T140000
DESCRIPTION:Speaker: Colinda Scheele\nhosted by Edouard Hannezo\nAbstract: 
 Oncogenic mutations are common in healthy tissues but rarely form tumors. 
 Using the mammary gland as a model\, we explored how tissue organization a
 nd dynamics affect mutant cell fate. Through lineage tracing and intravita
 l imaging\, we found that rounds of local tissue remodeling\, driven by th
 e estrous cycle led to the elimination of the majority of mutant clones. H
 owever\, it simultaneously enabled a minority of mutant clones\, that by c
 hance survived\, to geometrically expand. This expansion led to cohesive f
 ields of mutant cells spanning large parts of the mammary ducts\, predispo
 sing these ducts to tumor formation. Once tumors form\, breast cancer resp
 onse to neoadjuvant chemotherapy varies\, even within the same subtype. Ag
 ain\, we identified the estrous cycle as a key factor in this variability.
  In three mouse models\, NAC response was reduced when treatment began dur
 ing diestrus compared to estrus. Similar patterns were observed in retrosp
 ective premenopausal human cohorts\, highlighting the importance of treatm
 ent timing for improved chemotherapy outcomes.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B / 63 seats (I23.
 EG.102)\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Colinda Scheele: Natural tissue remodeling as driver for breast tum
 or initiation and treatment resistance
URL:https://talks-calendar.ista.ac.at/events/5635
END:VEVENT
END:VCALENDAR