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DTSTART:20160327T030000
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DTSTART:20161030T020000
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DTSTAMP:20260429T153831Z
UID:55488772a3467830206340@ist.ac.at
DTSTART:20160411T124500
DTEND:20160411T134500
DESCRIPTION:Speaker: Richard Tsien\nAbstract: The primary language of excit
 able cells (action potential firing) is converted into the primary languag
 e of intracellular activity (biochemical signaling) by voltage-gated Ca2+ 
 channels (CaVs). Such signaling is exemplified by excitation-contraction (
 E-C) coupling and excitation-secretion (E-S) coupling. Excitation-transcri
 ption (E-T) coupling is a more general event in excitable cells yet is les
 s understood. A subfamily of Ca2+ channels\, CaV1 (L-type) channels\, fulf
 ills a privileged role in excitation-transcription coupling to nuclear CRE
 B\, a transcription factor critical in learning and memory. However\, even
  the earliest step in this signaling pathway is not fully understood: loca
 l Ca2+ elevations near CaV1 channels are thought to be the main trigger in
  the signaling cascade\, but CaV1 channels could also convey a voltage-dep
 endent conformational signal (VCS) to nearby signaling intermediates\, lik
 e the conformational signal in E-C coupling. We have devised an approach w
 hereby conformational changes required to open the CaV pore are experiment
 ally decoupled from Ca2+ influx into the channel nanodomain. This dissecti
 on uncovered a remarkable requirement for the CaV1 VCS in excitation-trans
 cription coupling. CaV1 signaling to CREB behaves as an AND gate\, whereby
  both Ca2+ and voltage-dependent movements are necessary. The key local si
 gnaling intermediates include a-and bCaMKII.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Richard Tsien: The Institute Colloquium: Signaling from synapse to 
 nucleus for synaptic and behavior
URL:https://talks-calendar.ista.ac.at/events/562
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