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DTSTART:20250330T030000
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DTSTAMP:20260406T000400Z
UID:1739869200@ist.ac.at
DTSTART:20250218T100000
DTEND:20250218T110000
DESCRIPTION:Speaker: Andrea Cumpelik\nhosted by Jozsef Csicsvari\nAbstract:
  Making decisions requires flexibly adapting to changing environments. Thi
 s process depends on accurately interpreting current contingencies and int
 egrating them with past experience. Two brain regions are particularly cri
 tical for this process: the medial prefrontal cortex (mPFC) and the hippoc
 ampus. Using contextual information from the hippocampus\, the mPFC select
 s relevant cognitive frameworks and suppresses irrelevant ones to guide ap
 propriate actions. Several studies have shown that some mPFC pyramidal neu
 rons become spatially tuned when spatial information is required to guide 
 goal-directed behavior. However\, the role of prefrontal spatial represent
 ations in learning and decision making is not well understood. This work a
 ims to characterize the role of mPFC spatial tuning in supporting a novel 
 contextual association task. Rats were trained to learn two cue-location a
 ssociations on a radial arm maze over multiple days\, while we simultaneou
 sly recorded from dorsal CA1 of the hippocampus and the prelimbic area of 
 the mPFC. Successful task performance required rats to update a previously
  learned strategy. We describe a subset of spatially tuned hippocampal and
  prefrontal pyramidal neurons that “flicker” between multiple spatial 
 representations on different trials\, suggesting dynamic\, context-depende
 nt coding. This flickering may provide a substrate for how the network reo
 rganizes in response to task demands\, likely by enabling the flexible eva
 luation of competing representations.
LOCATION:Moonstone Building / Ground floor / Seminar Room G (124.EG.030g) a
 nd Zoom\, ISTA
ORGANIZER:
SUMMARY:Andrea Cumpelik: Thesis Defense: The role of prefrontal spatial cod
 ing in supporting a contextual association task
URL:https://talks-calendar.ista.ac.at/events/5559
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