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DTSTART:20160327T030000
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DTSTART:20151025T020000
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DTSTAMP:20260430T094603Z
UID:5548861af18ab063340055@ist.ac.at
DTSTART:20151214T124500
DTEND:20151214T140000
DESCRIPTION:Speaker: Daniel Choquet\nAbstract: The spatio-temporal organiza
 tion of neurotransmitter receptors in the postsynaptic membrane is a funda
 mental determinant of synaptic transmission and thus information processin
 g by the brain. Ionotropic AMPA glutamate receptors (AMPAR) mediate fast e
 xcitatory synaptic transmission in the central nervous system. Using a com
 bination of high resolution single molecule imaging techniques and video-m
 icroscopy\, we had previously established that AMPARs are not stable in th
 e synapse as thought initially\, but undergo continuous entry and exit to 
 and from the post-synaptic density through lateral diffusion.\nUsing three
  independent super-resolution imaging methods\, on both genetically tagged
  and endogenous receptors\, we have demonstrated that\, in live hippocampa
 l neurons\, AMPAR are highly concentrated inside synapses into a few clust
 ers of around seventy nanometers. AMPAR are stabilized reversibly in these
  domains and diffuse freely outside them. Nanodomains are themselves dynam
 ic in their shape and position within synapses as they can form and disapp
 ear within minutes\, although they are for the most part stable for at lea
 st up to an hour. These results open the new possibility that glutamatergi
 c synaptic transmission is controlled by the regulation at the nanometer s
 cale of the position and composition of these highly concentrated nanodoma
 ins. In support of this hypothesis\, we recently demonstrated that AMPAR c
 onformation strongly impacts their mobility\, indicating that desensitized
  AMPAR can escape synapses. This finding provides a functional support to 
 our hypothesis that fast AMPAR surface diffusion can tune short term plast
 icity by allowing fast replacement of desensitized AMPAR by naïve ones du
 ring high frequency stimulation.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Daniel Choquet: The Institute Colloquium: Interplay between glutama
 tergic synapse nanoscale organizat
URL:https://talks-calendar.ista.ac.at/events/555
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