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DTSTAMP:20260424T140751Z
UID:1742812200@ist.ac.at
DTSTART:20250324T113000
DTEND:20250324T123000
DESCRIPTION:Speaker: Andrea Pauli\nhosted by Carl-Philipp Heisenberg\nAbstr
 act: Life of sexually reproducing organisms starts with the fusion of two 
 highly specialized cells\, the egg and the sperm\, which gives rise to a s
 ingle cell\, the zygote. Fertilization initiates the egg-to-embryo transit
 ion\, one of the most dramatic developmental transition resulting in the t
 ransformation of the egg from a dormant state into regulatorily and functi
 onally distinct embryonic cells. While this transition has been studied ex
 tensively in respect to zygotic genome activation\, the molecular mechanis
 ms that mediate sperm-egg binding and fusion during fertilization and regu
 late the maintenance of dormancy in the egg and re-activation in the embry
 o remain poorly understood. The vision of the Pauli lab is to gain mechani
 stic insights into the egg-to-embryo transition\, with a specific focus on
  the molecular control of fertilization and developmentally programmed dor
 mancy and re-activation.Andrea (Andi) Pauli will talk about recent finding
 s from her lab related to their work towards uncovering the mechanism of v
 ertebrate fertilization and translational regulation during the egg-to-emb
 ryo transition. By combining genetic\, molecular\, cellular\, biochemical\
 , structural and genomics approaches in their main model organism\, the ze
 brafish\, the long-term vision of the Pauli lab is to unravel new concepts
  and molecular mechanisms governing this fascinating developmental transit
 ion that marks the beginning of life.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:Diana.Gruber@ista.ac.at
SUMMARY:Andrea Pauli: Fundamental Principles during the Egg-to-Embryo Trans
 ition
URL:https://talks-calendar.ista.ac.at/events/5542
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