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DTSTART:20160327T030000
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DTSTART:20151025T020000
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DTSTAMP:20260430T094416Z
UID:5548861af188d168260063@ist.ac.at
DTSTART:20151123T124500
DTEND:20151123T140000
DESCRIPTION:Speaker: Erik van Nimwegen\nAbstract: Although it is often taci
 tly assumed that gene regulatory interactions are finely tuned\, how accur
 ate gene regulation could evolve from a state without regulation is unclea
 r. Moreover\, gene expression noise would seem to impede the evolution of 
 accurate gene regulation\, and previous investigations have provided circu
 mstantial evidence that natural selection has acted to lower noise levels.
  I will discuss how\, by evolving a large library of synthetic E. coli pro
 moters de novo\, and comparing the noise properties of these synthetic pro
 moters with those of native E. coli promoters\, we found that\, contrary t
 o expectations\, synthetic promoters naturally exhibit low noise.\nThat is
 \, low noise is the default state of E. coli promoters\, implying that sel
 ection must have acted to increase the noise levels of a subset of E. coli
  promoters that are characterized by large expression plasticity and large
  numbers of regulatory sites. I will present a general theory of the inter
 play between gene expression noise and gene regulation that explains these
  observations. The theory shows that propagation of expression noise from 
 regulators to their targets is not an unwanted side-effect of regulation\,
  but rather acts as a rudimentary form of regulation that facilitates the 
 evolution of more accurate regulation.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Erik van Nimwegen: The Institute Colloquium
URL:https://talks-calendar.ista.ac.at/events/554
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