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DTSTART:20250330T030000
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BEGIN:VEVENT
DTSTAMP:20260424T040543Z
UID:1737536400@ist.ac.at
DTSTART:20250122T100000
DTEND:20250122T110000
DESCRIPTION:Speaker: Cihan Önal\nhosted by Jozsef Csicsvari\nAbstract: The
  medial habenula (MHb) is implicated in regulating emotional responses to 
 aversive events. Studies in zebrafish have identified a remarkable morphol
 ogical left-right asymmetry in the dorsal habenula (zebrafish equivalent o
 f mammalian MHb)-to-interpeduncular nucleus (IPN) pathway and its left-sid
 e specific role in modulating fear responses. However\, there is little ev
 idence for structural or functional lateralization in the mammalian MHb-IP
 N pathway.Here\, I investigated the synaptic properties of the left and ri
 ght MHb afferents to the IPN in mice and addressed whether these synaptic 
 connections selectively influence the expression of conditioned fear in mi
 ce. My findings reveal that each individual IPN neuron receives inputs fro
 m both left and right MHb. Electrophysiological recordings from the same p
 ostsynaptic IPN neurons demonstrate that the left MHb-originating synapses
  exhibit lower release probability and higher -aminobutyric acid type B re
 ceptor (GABABR)-mediated potentiation compared to the right MHb-originatin
 g synapses. Interestingly\, chemogenetic inhibition of cholinergic neurons
  in the left but not the right MHb significantly attenuated cue-dependent 
 fear recall. Furthermore\, conditional deletion of GABABR in the left MHb 
 interfered with the recall of cued fear memory\, whereas that in the right
  MHb neurons spared fear memory expression.Collectively\, I demonstrate a 
 functional asymmetry of the MHb in mice\, revealing a predominant role for
  GABABR-mediated signaling in the left MHb-IPN pathway in the modulation o
 f fear memories. These findings suggest that lateralized pathways could re
 present a fundamental principle in the neural regulation of emotion across
  species.
LOCATION:Central Bldg / O1 / Ballroom (I01.O1.006) and Zoom\, ISTA
ORGANIZER:
SUMMARY:Cihan Önal: Thesis Defense: Asymmetrical modulation of fear expres
 sion via GABAB receptors in the mouse medial habenula 
URL:https://talks-calendar.ista.ac.at/events/5511
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