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DTSTART:20250330T030000
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DTSTAMP:20260424T040716Z
UID:66c5afbdf19c4426886275@ist.ac.at
DTSTART:20250116T110000
DTEND:20250116T120000
DESCRIPTION:Speaker: Guillaume Charras\nhosted by Andela Saric\nAbstract: T
 he ability of tissues to sustain mechanical stress and avoid rupture is a 
 fundamental pillar of their function. Rupture in response to physiological
  levels of stress can be undesired\, for example resulting from disease or
  genetic mutations\, or be an integral part of developmental processes\, s
 uch as during blastocoel formation in mouse or leg eversion in flies. Desp
 ite its importance\, we know very little about rupture in cellularised tis
 sues because it is a multi-scale phenomenon that necessitates comprehensio
 n of the interplay between mechanical forces and biological processes at t
 he molecular and cellular scales. Using a combination of mechanical measur
 ements\, live imaging and computational modelling\, we characterise ruptur
 e in epithelial monolayers. We show that\, despite consisting of only a si
 ngle layer of cells\, monolayers can withstand surprisingly large deformat
 ions\, often accommodating several-fold increases in their length before r
 upture. At large deformation\, epithelia increase their stiffness multiple
 -fold in a process controlled by a supracellular network of keratin filame
 nts. Perturbing keratin organisation fragilises monolayers and prevents st
 rain stiffening. Using computational approaches\, we show that\, although 
 the kinetics of adhesive bond rupture ultimately control tissue strength\,
  tissue rheology and the history of deformation prior to failure set the s
 train and stress that the tissue reaches at the onset of fracture. Our dat
 a paint a picture of epithelia as versatile materials that combine resista
 nce to shocks with deformability when subjected to low strain rates.
LOCATION:Moonstone Bldg / Ground floor / Seminar Room F (I24.EG.030f)\, IST
 A
ORGANIZER:dmujagic@ist.ac.at
SUMMARY:Guillaume Charras: Rupture strength of living cell monolayers
URL:https://talks-calendar.ista.ac.at/events/5470
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