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DTSTART:20150329T030000
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DTSTAMP:20260501T002121Z
UID:55488324f1a20435161690@ist.ac.at
DTSTART:20150907T124500
DTEND:20150907T134500
DESCRIPTION:Speaker: Daniel Geschwind\nAbstract: Genomics and genetics have
  fulfilled their early promise for identification of risk genes contributi
 ng to neuropsychiatric disease. We have leveraged transcriptomic and netwo
 rk biology approaches to elucidate the normal structure of the human brain
  transcriptional network\, so as to understand how risk genes for autism s
 pectrum disorder (ASD) might affect the development of brain circuits. Our
  findings demonstrate that there is shared\, convergent biology and neurop
 athology involving transcriptional regulation\, synaptic function and micr
 oglial regulation of neural function. This work identifies key epochs cell
  types\, and molecular pathways where ASD risk genes are likely to act dur
 ing fetal brain development. We have also begun to use the same systems bi
 ology framework to explore convergence and divergence with other neurodeve
 lopmental disorders\, and to assess the utility of in vitro model systems 
 for studying human neural development. These studies provide a framework f
 or further functional investigation of disease mechanisms with a goal of a
 ccelerating therapeutic development.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Daniel Geschwind: The Institute Colloquium: Integrative genomics in
  human neuropsychiatric disease
URL:https://talks-calendar.ista.ac.at/events/547
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