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DTSTAMP:20260424T143342Z
UID:675713b28cf5f261835954@ist.ac.at
DTSTART:20250115T110000
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DESCRIPTION:Speaker: Somya Mani\nhosted by Filip Ruzicka (Vicoso group)\nAb
 stract: During biological development\, cells constantly assimilate signal
 s from other cells in the body in order to decide whether to divide\, diff
 erentiate\, migrate or die. While it is in general intractable to experime
 ntally observe the cellular interactions and decisions for all the cells i
 n a developing organism\, high throughput single cell transcriptomics stud
 ies allow us to infer cellular differentiation trajectories in the form of
  cell-type lineage maps (CTLM). Animal CTLMs display characteristic patter
 ns\, such as tree-like graph topologies\, and a dearth of cyclic different
 iation trajectories. In this work\, I explore how and why these patterns i
 n CTLMs might evolve using an agent-based model of cellular decisions.In t
 his talk\, I will describe my model and discuss some preliminary results r
 elating to small multicellular systems composed of 3 cell-types. My model 
 generates a rich variety of organisms with diverse developmental dynamics 
  some organisms display transient intermediate life stages which are remin
 iscent of juvenile stages of real organisms. A large fraction of the model
 s developmental dynamics ultimately produce organisms with stable cellular
  compositions\, while others tend to be unstable and either decay through 
 excessive cell-death or grow uncontrollably. I discuss how selection for o
 rganismal stability could steer the evolution of developmental CTLMs.
LOCATION:Sunstone Bldg / O1 / Big Office Meeting room (101) (I23.O1.101)\, 
 ISTA
ORGANIZER:fruzicka@ist.ac.at
SUMMARY:Somya Mani: Deciphering the evolution of developmental cell lineage
  maps using an agent-based model of cell-fate decisions
URL:https://talks-calendar.ista.ac.at/events/5462
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