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DTSTART:20150329T030000
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DTSTART:20151025T020000
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DTSTAMP:20260501T084727Z
UID:544f54ba18ec4305273056@ist.ac.at
DTSTART:20150602T110000
DTEND:20150602T120000
DESCRIPTION:Speaker: Mark Estelle\nAbstract: Auxin regulates a bewildering 
 array of processes throughout plant growth and development. This complexit
 y contrasts with the apparent simplicity of the auxin-signaling pathway. A
 uxin regulates transcription through the TIR1/AFB-Aux/IAA-ARF pathway. The
  hormone directly binds to the F-box protein of the SCFTIR1/AFB ubiquitin 
 protein ligase E3 and promotes an interaction with the Aux/IAA transcripti
 onal repressors\, thus stimulating their degradation and allowing ARF-depe
 ndent transcription. Emerging evidence suggests that the complexity of aux
 in response is determined by the combinatorial nature of the auxin-signali
 ng pathway. Further\, the core auxin signaling pathway is subject to both 
 negative and positive feedback loops. We are currently focusing on factors
  that regulate TIR1/AFB and Aux/IAA levels. We find that TIR1 is a client 
 of the chaperone HSP90 and is stabilized by both auxin and elevated temper
 ature. Further we demonstrate that the ALF4 protein\, previously shown to 
 be required for lateral root formation\, is an ortholog of the human glomu
 lin protein\, and regulates SCFTIR1 function. Finally\, we are studying ho
 w other environmental and developmental signals integrate with the auxin p
 athway by regulating transcription of the Aux/IAA genes.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Mark Estelle: The Institute Colloquium: Auxin: molecular glue that 
 drives plant development
URL:https://talks-calendar.ista.ac.at/events/542
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