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DTSTAMP:20260424T113944Z
UID:67289cc4d64be456545406@ist.ac.at
DTSTART:20241118T124500
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DESCRIPTION:Speaker: Rachael Dangarembizi\nhosted by Tim Vogels\nAbstract: 
 Fungi have been allies to humanity since the beginning of our existence\, 
 aiding in the production of food\, beverages\, and even treatments for hum
 an ailments. However\, in recent times\, invasive fungal infections have e
 merged as a significant threat to human health\, an adversary for which we
  currently lack adequate defences.We study the pathobiology of cryptococca
 l meningitis\; a highly invasive and deadly fungal infection of the centra
 l nervous system (CNS) caused by the ubiquitous fungus Cryptococcus neofor
 mans. C. neoformans is a neuroinvasive and neurotropic yeast that is assoc
 iated with a lethal form of meningoencephalitis (inflammation of the menin
 ges and neural tissue). Patients with CM develop severe neurological damag
 e but the mechanisms driving brain injury in this fatal disease remain poo
 rly described.Using both mouse and human brain tissue models\, we have cha
 racterized host-fungus interactions at cellular and molecular levels. Our 
 findings reveal that fungi can evade immune destruction in the peripheral 
 system\, penetrate the brain via its extensive vascular network\, and disr
 upt neuroimmune balance\, resulting in both hypo- and hyperinflammatory re
 sponses. This dysregulation leads to injury and neurological damage. We fu
 rther demonstrate how fungal invasion impairs fluid and waste homeostasis 
 in the brain\, exacerbating inflammation and tissue damage.
LOCATION:Office Bldg West / Ground floor / Heinzel Seminar Room (I21.EG.101
 )\, ISTA
ORGANIZER:jdeanton@ist.ac.at
SUMMARY:Rachael Dangarembizi: Cryptococcal wars: battles of the brain with 
 killer fungi
URL:https://talks-calendar.ista.ac.at/events/5376
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