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DTSTART:20150329T030000
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DTSTART:20151025T020000
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DTSTAMP:20260501T140124Z
UID:53ec671d8ccd3043058184@ist.ac.at
DTSTART:20150413T163000
DTEND:20150413T173000
DESCRIPTION:Speaker: Sally Otto\nAbstract: As evolutionary biologists\, we 
 are only now getting a clear picture of the genetic basis of adaptation. T
 hrough genomic sequencing\, we can pinpoint the mutations responsible for 
 adaptation and use these mutations to parameterize models and to test evol
 utionary theory\, providing a much sounder empirical basis for this theory
 . In this talk\, I will describe experiments with Saccharomyces cerevisiae
  aimed at clarifying the nature and distribution of beneficial mutatioins.
  A panel of independent adaptive mutations was obtained by exposing haploi
 d yeast to harsh environmental conditions: a fungicide (nystatin) or toxic
  levels of copper. The array of mutations allowing adaptation to the eithe
 r environment was determined by genome-wide sequencing of 35 different ada
 pted lines from each of the two environments. This panel was then used to 
 measure trade-offs among environments and among ploidy levels\, as well as
  properties such as dominance across environments. The implications for Ha
 ldane's sieve and the role of ploidy in adaptation will be discussed.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Sally Otto: The Institute Colloquium: Genomic scope of adaptive mut
 ations in the face of an envir
URL:https://talks-calendar.ista.ac.at/events/536
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