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TZID:Europe/Vienna
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DTSTART:20150329T030000
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DTSTART:20141026T020000
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DTSTAMP:20260501T152833Z
UID:53ec671d8ccae922708768@ist.ac.at
DTSTART:20150309T163000
DTEND:20150309T173000
DESCRIPTION:Speaker: Aurélien Roux\nAbstract: ESCRT-III is required for li
 pid membrane remodeling in many cellular processes\, from abscission to vi
 ral budding and multi-vesicular body biogenesis. However\, how ESCRT-III p
 olymerization generates membrane curvature remains debated. Here we show t
 hat Snf7\, the main component of ESCRT-III\, polymerizes into spirals at t
 he surface of lipid bilayers. When covering the entire membrane surface\, 
 these spirals stopped growing when densely packed: they had a polygonal sh
 ape\, suggesting that lateral compression could deform them. We reasoned t
 hat Snf7 spirals could function as spiral springs. By measuring the polyme
 rization energy and the rigidity of Snf7 filaments\, we showed that they w
 ere deformed while growing in a confined area. Furthermore\, we observed t
 hat the elastic expansion of compressed Snf7 spirals generated an area dif
 ference between the two sides of the membrane and thus curvature. This spr
 ing-like activity underlies the driving force by which ESCRT-III could med
 iate membrane deformation and fission.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Aurélien Roux: The Institute Colloquium: Role of lateral compressi
 on of ESCRT spiral springs in memb
URL:https://talks-calendar.ista.ac.at/events/534
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