BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20150329T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20141026T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260501T200632Z
UID:5004045117eee@ist.ac.at
DTSTART:20141110T163000
DTEND:20141110T173000
DESCRIPTION:Speaker: Anne-Claude Gavin\nAbstract: Eukaryotic cells use memb
 rane-bounded organelles with unique lipid and protein compositions to regu
 late and spatially organize cellular functions and signalling. As part of 
 this tight control\, many proteins are regulated by lipids. In humans\, th
 e importance of these regulatory circuits is evident from the variety of d
 isorders arising from altered protein–lipid interactions\, which constitu
 te attractive targets for pharmaceutical drug development. However\, the f
 ull repertoire of interactions remains poorly explored and exploited becau
 se their detection is still difficult to achieve on a large\, systematic s
 cale. I will describe a series of chemical biology approaches to character
 ize in vivo assembled\, stable protein-lipid complexes and to study lipid 
 interactions with peripheral membrane proteins. Data from yeast and human 
 cell lines reveal surprising insights\, such as the discovery of a new fam
 ily of oxysterol-binding protein\, conserved in humans (where it has been 
 linked to several diseases) with unexpected specificities for an important
  signaling lipid\, phosphatidylserine. The assays are scalable to the prot
 eome and/or lipidome levels and are easily adapted to the study of small-m
 olecules that disrupt protein–lipid interactions.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:ihetzenauer@ist.ac.at
SUMMARY:Anne-Claude Gavin: Institute Colloquium: Expanding the cellular int
 eractome: protein-lipid networks
URL:https://talks-calendar.ista.ac.at/events/526
END:VEVENT
END:VCALENDAR