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DTSTART:20180325T030000
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DTSTAMP:20260406T074340Z
UID:577e16ccec720589384503@ist.ac.at
DTSTART:20180618T160000
DTEND:20180618T170000
DESCRIPTION:Speaker: Alysson Muotri\nhosted by Gaia Novarino\nAbstract: The
  complexity of the human brain\, with thousands of neuronal types\, permit
 s the development of sophisticated behavioral repertoires\, such as langua
 ge\, tool use\, self-awareness\, symbolic thought\, cultural learning and 
 consciousness. Understanding what produces neuronal diversification during
  brain development has been a longstanding challenge for neuroscientists a
 nd may bring insights into the evolution of human cognition. Human pluripo
 tent stem cells have the ability to differentiate in specialized cell type
 s\, such as neurons and glia. Moreover\, induced pluripotent stem cells ca
 n be achieved from living individuals by reprogramming somatic cells that 
 would capture their entire genome in a pluripotent state. From these pluri
 potent state\, it is possible to generate models of the human brain\, such
  as brain organoids. We have been using brain-model technology (BMT) to ga
 in insights on several biological processes\, such as human neurodevelopme
 nt and evolution. We also applied BMT to measure the impact of genetic var
 iants in autism spectrum disorders and for evolutionary studies. The recon
 struction of human synchronized network activity in a dish can help to und
 erstand how neural network oscillations might contribute to the social bra
 in. Our findings suggest a potential bridge to the gap between the microsc
 ale in vitro neural networks electrophysiology and non-invasive electroenc
 ephalogram.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:kzaruba@ist.ac.at
SUMMARY:Alysson Muotri: Emergence of spontaneous oscillatory networks from 
 human brain organoids
URL:https://talks-calendar.ista.ac.at/events/52
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