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DTSTART:20140330T030000
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DTSTAMP:20260502T061401Z
UID:50040450d9252@ist.ac.at
DTSTART:20140519T163000
DTEND:20140519T173000
DESCRIPTION:Speaker: Michisuke Yuzaki\nAbstract: Recent two-photon confocal
  laser microscopic imaging in vivo has provided evidence that excitatory s
 ynapses are rapidly generated or eliminated in the CNS in response to neur
 onal activity\, not only during development but also throughout adulthood.
  The mechanisms that govern these processes are fundamental to our underst
 anding of neural plasticity involved in learning and memory. In the last d
 ecade\, many molecules that directly regulate the formation and maturation
  of synapses\, which are collectively referred to as synaptic organizers\,
  have been identified. However\, it has been unclear how various synaptic 
 organizers operate to organize different aspects of synapse formation and 
 differentiation in vivo.\nWe have recently identified a new class of synap
 tic organizers that belong to the C1q family. C1q is a target recognition 
 protein of the classical complement pathway in the innate immune system. C
 1q family proteins\, which share the C-terminal globular domain of C1q\, a
 re mostly secreted and involved in various intercellular signaling. We fou
 nd that Cbln1 is secreted from cerebellar granule cells and binds to its p
 resynaptic receptor neurexin located on granule cell axons and its postsyn
 aptic receptor the delta2 glutamate receptor (GluD2) on dendritic spines o
 f Purkinje cells. The neurexin/Cbln1/GluD2 tripartite complex serves as a 
 unique bidirectional synaptic organizer in the cerebellum. In addition\, C
 bln1 and its family members\, Cbln2–Cbln4\, are expressed in various regi
 ons of developing and mature brains. Furthermore\, a related family C1ql1-
 C1ql4 is highly expressed in various brain regions. In this talk\, I would
  like to introduce and discuss some of our recent findings on the C1q fami
 ly proteins.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:ihetzenauer@ist.ac.at
SUMMARY:Michisuke Yuzaki: Institute Colloquium: The more the merrier—compl
 ement family of synaptic organizers
URL:https://talks-calendar.ista.ac.at/events/513
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