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DTSTAMP:20260407T051550Z
UID:1721293200@ist.ac.at
DTSTART:20240718T110000
DTEND:20240718T120000
DESCRIPTION:Speaker: Balint Kiraly\nhosted by Max Joesch\nAbstract: Neuromo
 dulatory systems often regulate seemingly overlapping cognitive processes 
 and show similar modes of action. To reveal possible synergistic or antago
 nistic relations and to better understand the exact role of these systems\
 , in a comprehensive series of experiments\, we simultaneously monitored p
 airs of neuromodulatory systems in mice performing a series of behavioral 
 tasks focusing on different aspects and mechanisms of learning\, such as p
 sychometric operant learning and implicit statistical learning. In the exa
 mined subcortical target areas (the ventral striatum and the basolateral a
 mygdala)\, we observed robust\, rapid\, strongly correlated but not synchr
 onous event-related release of dopamine and acetylcholine\, linked to beha
 vioral feedback and outcome predictions in all tasks\, which closely resem
 bled the spiking activity of their deep brain neuronal source (the ventral
  tegmental area and the diagonal band of Broca\, respectively). On the oth
 er hand\, other neuromodulators (serotonin and noradrenalin) and neuromodu
 lator release in the prefrontal cortex in general\, were more characterize
 d by a slower oscillatory alteration\, yet also in a task-dependent manner
 \, entrained by behaviorally salient events. Our results indicate that mul
 tiple modes of learning rely on a precisely coordinated release of various
  neuromodulators\, which act on a somewhat heterogeneous manner across dif
 ferent brain areas.
LOCATION:Mondi 3\, ISTA
ORGANIZER:
SUMMARY:Balint Kiraly: Correlations in neuromodulatory codes during differe
 nt learning processes
URL:https://talks-calendar.ista.ac.at/events/5116
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