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DTSTAMP:20260405T162341Z
UID:6683f73a78569643771610@ist.ac.at
DTSTART:20240715T160000
DTEND:20240715T170000
DESCRIPTION:Speaker: Yasuo Mori\nhosted by Shigemoto Group\nAbstract: A str
 ict demand for molecular oxygen (O2) is imposed on us absolutely aerobic o
 rganisms to maintain metabolic activity through mitochodrial ATP productio
 n\, while depletion of O2 (hypoxia) promptly endangers our survival. Altho
 ugh this recognition concerning biological significance of O2 may appear o
 bligatory and undeniable\, it is in fact malleable and ambiguous from the 
 perspective of in vivo significance of O2 in multicellular organisms. Rece
 ntly\, evidence has accumulated that hypoxia underlies various physiologic
 al responses in cells and organs. In addition\, within the body\, O2 has b
 een shown to be endogenously converted to the reactive molecular species r
 esponsible for oxidative stress that influences and often dysregulates dow
 nstream cellular signals. In this lecture\, it is highlighted that a Ca2+-
 permeable cation channel TRPA1 constitutes the sensors of O2 and its relat
 ed derivatives to activate downstream electrical/chemical signals in the p
 eripheral and central nervous system. Also\, by discussing how the TRPA1-m
 ediated mechanism contributes to the setting of hypoxic level of O2\, I wi
 ll attempt to robustify and conceptualize physiological aspects of hypoxia
  as physioxia.
LOCATION:Moonstone Bldg / Ground floor / Seminar Room G (I24.EG.030g)\, IST
 A
ORGANIZER:dshaybaz@ist.ac.at
SUMMARY:Yasuo Mori: Molecular oxygen can be an awkward demand of us absolut
 ely aerobic organisms
URL:https://talks-calendar.ista.ac.at/events/5085
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