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DTSTAMP:20260405T182533Z
UID:1720177200@ist.ac.at
DTSTART:20240705T130000
DTEND:20240705T140000
DESCRIPTION:Speaker: Alberto Danieli\nhosted by Martin Loose\nAbstract: Sel
 ective autophagy mediates the removal of harmful ubiquitinated proteins fr
 om the cytoplasm. Ubiquitinated proteins are clustered in a p62-dependent 
 manner and are subsequently engulfed by autophagosomes to be delivered int
 o lysosomes. However\, the nature of the protein substrates targeted for a
 utophagy is unclear. First\, we developed a reconstituted system using pur
 ified components and showed that p62 and ubiquitinated proteins spontaneou
 sly coalesce into larger clusters and we demonstrated that efficient clust
 er formation is based on p62 filaments cross-linked by the ubiquitinated s
 ubstrates. Second\, to obtain insights into their composition\, we develop
 ed a method to isolate p62 condensates and found that they are enriched in
  components of the translation machinery. Furthermore\, p62 interacts with
  translation initiation factors and eIF2α and eIF4E are degraded by autop
 hagy in a p62 dependent manner. These studies provided mechanistic insight
 s on how substrates are channelled into autophagy and showed how p62-media
 ted autophagy may in part be linked to aberrant translation initiation.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B / 63 seats \, IS
 TA
ORGANIZER:
SUMMARY:Alberto Danieli: Insight into p62 mediated condensation and cargoes
  recognition
URL:https://talks-calendar.ista.ac.at/events/5084
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