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DTSTAMP:20260425T075201Z
UID:1713859200@ist.ac.at
DTSTART:20240423T100000
DTEND:20240423T113000
DESCRIPTION:Speaker: William Henriques\nhosted by Alicia Michael\nAbstract:
  Viruses are the most numerous and diverse biological entities on the plan
 et. Their constant predation of hosts drives the diversification of defens
 e and counter-defense systems in an endless genetic conflict for cellular 
 resources. A subset of viruses and defense systems function as wild genome
  “authors” through evolved strategies to physically integrate foreign 
 nucleic acid into the host genome. In this seminar\, I will discuss how on
 e such wild genome author used by CRISPR-Cas defense systems folds the gen
 ome to insert foreign nucleic acid into a precise location genome for CRIS
 PR-mediated viral defense. Though some defense systems rely on genomic int
 egration for successful defense\, far more viruses and genetic parasites u
 se genome integration as a replication strategy. I will also discuss a rar
 e but important evolutionary outcome of viral integration. In five indepen
 dent instances\, viral integration in the germline of an ancient vertebrat
 e gave rise to genes and gene families that are now essential in modern ma
 mmals.
LOCATION:Moonstone Building\, Ground Floor\, Seminar Room E\, ISTA
ORGANIZER:alicia.michael@ista.ac.at
SUMMARY:William Henriques: Talk: The viral authors of evolution
URL:https://talks-calendar.ista.ac.at/events/4926
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