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DTSTART:20130331T030000
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DTSTART:20131027T020000
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DTSTAMP:20260504T160657Z
UID:500404509988a@ist.ac.at
DTSTART:20131007T163000
DTEND:20131007T173000
DESCRIPTION:Speaker: Brian Chait\nAbstract: The myriad events that occur in
  living cells (replication\, organellar assembly\, transport\, genome\norg
 anization\, transcription etc.) are to a large extent carried out through 
 dynamic associations and\nassemblies of macromolecules. I will describe ou
 r efforts to develop and integrate sets of tools\nthat are designed to thr
 ow light on the evolution\, structure and function of these macromolecular
 \nmachines.\nAt the very earliest stage of analysis\, we define the precis
 e ensembles of macromolecular players\nthat make up the assemblies of inte
 rest. Mass spectrometry has become an increasingly enabling\ntool for this
  task\, owing to its sensitivity and its ability to characterize the prima
 ry structures of\nendogenous proteins along with any modifications that ma
 y be present. At the next stage of\nanalysis\, we apply combined proteomic
 -biochemical approaches to gain insights into the\narchitectures of protei
 n complexes\, especially those that are too large or too poorly behaved fo
 r\ntraditional X-ray crystallographic diffraction or NMR spectroscopic ana
 lyses. Finally\, we integrate\ndata from all these sources to generate mod
 els that can provide insights into the evolution\,\nstructure and function
  of these remarkable macromolecular machines. I will to discuss current\nc
 apabilities and limits of this approach as well as prospects for the futur
 e.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:ihetzenauer@ist.ac.at
SUMMARY:Brian Chait: The Institute Colloquium: Hybrid methods for defining 
 the structure and function of c
URL:https://talks-calendar.ista.ac.at/events/491
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