BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20240331T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20241027T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260405T232558Z
UID:1716300000@ist.ac.at
DTSTART:20240521T160000
DTEND:20240521T170000
DESCRIPTION:Speaker: Harris Kaplan\nhosted by Sweeney Group\nAbstract: How 
 does animal behavior emerge developmentally? This question\, and particula
 rly the underlying contributions of genetic versus environmental informati
 on\, has been fiercely debated by generations of scientists\, leading Niko
 laas Tinbergen to codify developmental issues as one of his Four Questions
  in the study of animal behavior. Despite this historical spotlight\, mode
 rn studies of neuronal circuit development have largely focused on sensory
  systems or prenatal stages. To gain insight into behavior development\, w
 e focused on the preoptic area (POA) of the hypothalamus. Recent work has 
 identified molecularly defined neuronal types in the POA that appear dedic
 ated to specific social behaviors (e.g. mating or parenting) or homeostati
 c functions (e.g. sleep or thirst). However\, this work has been carried o
 ut exclusively in adults\; how these cell types emerge developmentally rem
 ains unknown. We molecularly profiled POA cell types in mice using single-
 nucleus RNA-sequencing and paired ATAC-sequencing at eight ages from late 
 embryo to adult. We identified key stages of POA development\, including t
 he perinatal emergence of sex differences\, postnatal maturation of signal
 ing networks\, and nonlinear transcriptional changes accelerating at the t
 ime of weaning and puberty. We next asked how POA development is affected 
 by environmental inputs by examining five mutant lines\, each impaired in 
 a specific sensory modality crucial for POA function. This uncovered a maj
 or role for vomeronasal input in POA cell type maturation\, while other se
 nsory inputs have little to no effect. Altogether\, our work paints a pict
 ure of POA development as surprisingly sensitive to extrinsic factors\, an
 d lays the foundation for future work addressing the origin of instinctive
  behaviors and their control at various life stages.
LOCATION:Mondi 2\, Central Building\, ISTA
ORGANIZER:dayana.shaybazyan@ist.ac.at
SUMMARY:Harris Kaplan: Instinctive behavior circuit development is shaped b
 y sensory input\, sex\, and function
URL:https://talks-calendar.ista.ac.at/events/4896
END:VEVENT
END:VCALENDAR