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DTSTART:20130331T030000
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DTSTART:20131027T020000
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BEGIN:VEVENT
DTSTAMP:20260504T172037Z
UID:5004045091e90@ist.ac.at
DTSTART:20130909T163000
DTEND:20130909T173000
DESCRIPTION:Speaker: Carol A. Barnes\nAbstract: Aging is associated with sp
 ecific impairments of learning and memory\, some of which are similar\nto 
 those caused by damage to temporal or frontal lobe structures. For example
 \, healthy older\nhumans\, monkeys and rats all show poorer spatial\, reco
 gnition and working memory\, than do\ntheir younger counterparts. Rats and
  monkeys do not develop age-related pathology such as\nAlzheimer’s and Pa
 rkinson’s diseases\, which makes them good models for assessing functiona
 l\nalterations associated with normal aging in humans. While many cellular
  properties of medial\ntemporal lobe cells appear to be intact in aging an
 imals\, age-related impairments in synaptic\nfunction\, plasticity and gen
 e expression have been observed. Because information is represented\nby ac
 tivity patterns across large populations of neurons\, an understanding of 
 the neural basis of\ncognitive changes in aging requires the examination o
 f the dynamics of behaviorally-driven neural\nnetworks. Ensemble recording
  experiments are described that suggest fundamental changes in\nthe storag
 e and retrieval of information\, as well as in high level perceptual proce
 ssing in aging\nhippocampal and perirhinal cortical circuits. In addition\
 , frontal cortical correlates of working\nmemory are discussed. Together t
 he evidence suggests that normative aging processes show both\ncell type a
 nd region specificity\, and rather than uniform deterioration\, the aging 
 brain can show\nchanges consistent with adaptive\, compensatory processes.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:ihetzenauer@ist.ac.at
SUMMARY:Carol A. Barnes: The Institute Colloquium: Normal brain aging: Impa
 ct on circuits critical for memory
URL:https://talks-calendar.ista.ac.at/events/489
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