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UID:659e52aa7b61d439356457@ist.ac.at
DTSTART:20240409T110000
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DESCRIPTION:Speaker: Laura Alvarez\nhosted by Andela Saric\nAbstract: Bioin
 spired microdevices are the prelude to a great advance in biomedical techn
 ologies. However\, there is a clear gap in fabricating prototypes of the s
 ize and complexity of cells [1]. Active colloids are an experimental parad
 igm to realize microrobots due to their ability to self-propel and perform
  simple tasks [2\, 3]\, yet they fail to provide autonomous units due to t
 heir limited geometries and materials\, and lack of autonomy. How can we p
 ush the experimental limits and realize bioinspired microscale devices?Her
 e\, I will demonstrate that using soft and adaptive building blocks is the
  key to a new generation of biomimetic active colloids. In particular\, I 
 will show our recent results on the fabrication of cell-like active assemb
 lies using giant unilamellar vesicles (GUVs) under external actuation [4].
  In contrast to the traditional active colloids\, active GUVs present an e
 xcellent cell-model system\, thanks to their membrane permeability and abi
 lity to enclose nano and micro-objects. We report on their run-and-tumble 
 dynamics\, reminiscent of bacteria dynamic patterns. We further explore th
 eir ability to deform and divided when applying external fields. The propo
 sed cell-like architecture reveals exciting opportunities for the developm
 ent of soft and adaptive active microdevices with in-built feedback via bo
 ttom-up approaches.Fig 1. Fluorescence microscopy picture of phase-separat
 ed active Janus vesicle driven by AC electric field. The motion of the ves
 icle undergoes runs and tumbles\, due to the transient mixing of the lipid
  domains.[1] Nelson BJ\, Kaliakatsos IK\, Abbott JJ. Microrobots for minim
 ally invasive medicine. Annu. Rev. Biomed. Eng. 15\, 55 (2010)[2] Alvarez\
 , L.*\, Fernandez-Rodriguez M.A.\, Alegria A.\, Zhao\, K.\, Kruger\, M.\, 
 Isa\, L.*\, Reconfigurable Artificial Microswimmers with Internal Feedback
 . Nature Communications\, 12\, 4762 (2021)[3] van Kesteren\, S.\, Alvarez\
 , L.\, Arrese-Igor\, S.\, Alegría\, A.\, Isa\, L*\, Self-propelling collo
 idal finite state machines. PNAS\, 120\, e2213481120 (2023)[4] Willems\, V
 .\, Baron A.\, Matoz-Fernandez\, D.\, Wolisfberg\, G.\, Dufresne\, E.\, Al
 varez\, L*. Phase-separation dependent active motion of Janus Vesicles. Ar
 Xiv (under review\, 2023)
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B / 63 seats (I23.
 EG.102)\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Laura Alvarez: Soft and adaptive active systems: towards cell-mimet
 ic microdevices
URL:https://talks-calendar.ista.ac.at/events/4868
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