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BEGIN:VEVENT
DTSTAMP:20260424T052056Z
UID:1708952400@ist.ac.at
DTSTART:20240226T140000
DTEND:20240226T150000
DESCRIPTION:Speaker: Johannes Schwab\nhosted by Florian Schur\nAbstract: Si
 ngle-particle cryo-EM images emerge from many diverse observations of the 
 same molecule\, where flexible areas of it result in a local drop of resol
 ution in a single 3D reconstruction. We introduce DynaMight\, a software i
 ntegrated in RELION 5.0\, that employs machine learning techniques to esti
 mate smooth deformation fields of a Gaussian model for every projection im
 age. DynaMight can be used it to visualize the flexibility of a sample\, s
 elect a subset of particles\, and incorporate all images into an improved 
 reconstruction. Using a filtered backprojection algorithm along curved lin
 es computed from the estimated deformations\, we are able to better resolv
 e the flexible regions. We demonstrate that the estimated deformation alon
 gside with the modified reconstruction algorithm yields improved 3D recons
 tructions on experimental data.
LOCATION:Mondi 2\, ISTA
ORGANIZER:judit.gazsi@ist.ac.at
SUMMARY:Johannes Schwab: Estimating molecular motions from cryo-EM images w
 ith DynaMight
URL:https://talks-calendar.ista.ac.at/events/4779
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